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Peyronie’s Disease

Home » Specialties » Urology » Peyronie's Disease

Peyronie’s disease is curvature of the penis while erect due to plaque buildup in the connective tissues of the portion of the penis responsible for erections. This can make intercourse difficult or impossible.

The exact cause of peyronie’s disease is unknown, but may be caused by trauma or surgical scarring.


Typically, onset of the disease is marked by an initial, gradual change in curvature lasting anywhere from months to a couple years, and typically causes pain. During this period, roughly one-third improve, one-third stay the same, and one-third worsen. A point of stability will be reached and the pain typically resolves - this is when patients are eligible for treatment.


Treatment options are primarily aimed at enabling the patient to engage in intercourse. Current options include surgical straightening procedures, an medication injection such as Xiaflex® performed in the office, or a penile prosthesis for those also experiencing severe erectile dysfunction.

Xiaflex® Injection

Xiaflex is a medication which is injected into the penis to cause a breakdown of the plaques which cause Peyronie’s disease. This is done as an office procedure.

If the curvature is stable for at least 6 months and greater than 30 degrees, you may be a candidate for Xiaflex.

Additional information can be found here.