Peyronie’s disease is curvature of the penis while erect. This arises from a plaque in the connective tissues of the portion of the penis responsible for erections. This can make intercourse difficult or impossible. The exact cause of peyronie’s disease is unknown, but may be caused by trauma or surgical scarring.
Typically the curvature goes through an initial change lasting months to a couple years and typically has pain. During this period roughly 1/3 improve, 1/3 stay the same, and 1/3 worsen. A point of stability will be reached and the pain typically resolves and this is when patients are eligible for treatment.
Treatments are aimed at enabling the patient to engage in intercourse. Current options include an medication injection such as Xiaflex® performed in the office, surgical straightening procedures and penile prosthesis for those with severe erectile dysfunction as well.